5-Bromopyridine-3-sulfonyl chloride → 6-[(5-Bromo-3-pyridinyl)sulfonyl]-1-(4-fluorophenyl)-4a-(methoxymethyl)-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinoline

HRID 194489Notes

Reaction equation

HRID 194489 reaction equation
[Br:31][c:32]1[cH:33][c:34]([S:38](=[O:39])(=[O:40])[Cl:41])[cH:35][n:36][cH:37]1.[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][C:10]2([CH2:28][O:29][CH3:30])[CH2:11][c:12]3[c:13]([n:18](-[c:21]4[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]4)[n:19][cH:20]3)[CH:14]=[C:15]2[CH2:16][CH2:17]1)([CH3:5])([CH3:6])[CH3:7]>>[N:8]1([S:38]([c:34]2[cH:33][c:32]([Br:31])[cH:37][n:36][cH:35]2)(=[O:39])=[O:40])[CH2:9][C:10]2([CH2:28][O:29][CH3:30])[CH2:11][c:12]3[c:13]([n:18](-[c:21]4[cH:22][cH:23][c:24]([F:27])[cH:25][cH:26]4)[n:19][cH:20]3)[CH:14]=[C:15]2[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 203244745-Bromopyridine-3-sulfonyl chlorideHCID 66779666Tert-butyl 1-(4-fluorophenyl)-4a-(methoxymethyl)-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinoline-6-carboxylate

Product 1

HCID 667796716-[(5-Bromo-3-pyridinyl)sulfonyl]-1-(4-fluorophenyl)-4a-(methoxymethyl)-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinoline

Sources & evidence

ORD record
ord-6fc8a1d0988941bb946e6500ba62118c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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