HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-aminophenethylcarbamate → tert-Butyl 4-[3-[[3-carbamoyl-4-[(3-methoxyphenyl)amino]-8-methylquinolin-6-yl]sulfonyl]benzamido]phenethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-aminophenethylcarbamate | HCID 382207 | — |
| Reactant | 6-[[3-[(8-Hydroxyoctyl)carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | HCID 66988028 | — |
| Product | tert-Butyl 4-[3-[[3-carbamoyl-4-[(3-methoxyphenyl)amino]-8-methylquinolin-6-yl]sulfonyl]benzamido]phenethylcarbamate | HCID 58505121 | — |
Reaction Steps
The title compound was synthesized in a manner analogous to that described for Intermediate 70, using Intermediate 27 in place of 8-aminooctanol. 1H NMR (400 MHz, DMSO-d6) δ510.80 (s, 1H), 10.46 (s, 1H), 9.09 (s, 1H), 8.25-8.39 (m, 3H), 8.21 (d, J=7.9 Hz, 1H), 8.04 (s, 1H), 7.87 (d, J=8.0 Hz, 1H), 7.72-7.80 (m, 2H), 7.69 (d, J=8.4 Hz, 2H), 7.20 (d, J=8.4 Hz, 2H), 7.11 (t, J=8.0 Hz, 1H), 6.88 (t, J=5.4 Hz, 1H), 6.60-6.68 (m, 2H), 6.52 (d, J=8.3 Hz, 1H), 3.60 (s, 3H), 3.08-3.18 (m, 2H), 2.65-2.73 (m, 5H), 1.40 (s, 9H); ES/MS calcd. for C38H40N6O7S+ 710.3. Found m/z=710.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394829B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-60e97daaf0464779a2660407bf1d6b82 |
| Source note | uspto-grants-2013_03 |