HRID1944923

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57516944

未命名化合物

结构：CN(CCCC#Cc1ccc(NC(=O)C(F)(F)F)cc1)C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12

HCID58505093

未命名化合物

PRODUCTS

生成物

结构：CN(CCCC#Cc1ccc(N)cc1)C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12

HCID58505222

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described for Intermediate 49, using instead Intermediate 102 as a substrate. ES/MS calcd. for C29H40N3O3Si+ 506.3. Found m/z=506.4 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-261dcbd12ff94056826895355b3e6637
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394829B2
来源说明: uspto-grants-2013_03

反应 SMILES

CNC1C=CC(C#CCCCO)=CC=1.[Si:15]([O:22][C@H:23]([C:45]1[CH:54]=[CH:53][C:52]([OH:55])=[C:51]2[C:46]=1[CH:47]=[CH:48][C:49](=[O:56])[NH:50]2)[CH2:24][N:25]([CH3:44])[CH2:26][CH2:27][CH2:28][C:29]#[C:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37]C(=O)C(F)(F)F)=[CH:33][CH:32]=1)([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]>>[NH2:37][C:34]1[CH:35]=[CH:36][C:31]([C:30]#[C:29][CH2:28][CH2:27][CH2:26][N:25]([CH3:44])[CH2:24][C@@H:23]([C:45]2[CH:54]=[CH:53][C:52]([OH:55])=[C:51]3[C:46]=2[CH:47]=[CH:48][C:49](=[O:56])[NH:50]3)[O:22][Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:16])[CH3:17])=[CH:32][CH:33]=1