HCID 57516944, compound → HCID 58505222, compound

HRID 1944923Notes

Reaction equation

HRID 1944923 reaction equation
CNC1C=CC(C#CCCCO)=CC=1.[Si:15]([O:22][C@H:23]([C:45]1[CH:54]=[CH:53][C:52]([OH:55])=[C:51]2[C:46]=1[CH:47]=[CH:48][C:49](=[O:56])[NH:50]2)[CH2:24][N:25]([CH3:44])[CH2:26][CH2:27][CH2:28][C:29]#[C:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37]C(=O)C(F)(F)F)=[CH:33][CH:32]=1)([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]>>[NH2:37][C:34]1[CH:35]=[CH:36][C:31]([C:30]#[C:29][CH2:28][CH2:27][CH2:26][N:25]([CH3:44])[CH2:24][C@@H:23]([C:45]2[CH:54]=[CH:53][C:52]([OH:55])=[C:51]3[C:46]=2[CH:47]=[CH:48][C:49](=[O:56])[NH:50]3)[O:22][Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:16])[CH3:17])=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 57516944HCID 57516944, compoundHCID 58505093(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Product 1

HCID 58505222HCID 58505222, compound

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 49, using instead Intermediate 102 as a substrate. ES/MS calcd. for C29H40N3O3Si+ 506.3. Found m/z=506.4 (M+H)+.

Sources & evidence

ORD record
ord-261dcbd12ff94056826895355b3e6637
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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