6-((3-((4-(6-Hydroxyhex-1-yn-1-yl)phenyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide → HCID 86659094, compound

HRID 1944932Notes

Reaction equation

HRID 1944932 reaction equation
COC1C=C(NC2C3C(=C(C)C=C(S(C4C=CC=C(C(=O)NCCCCCCCC=O)C=4)(=O)=O)C=3)N=CC=2C(N)=O)C=CC=1.[OH:45][CH2:46][CH2:47][CH2:48][CH2:49][C:50]#[C:51][C:52]1[CH:57]=[CH:56][C:55]([NH:58][C:59]([C:61]2[CH:62]=[C:63]([S:67]([C:70]3[CH:71]=[C:72]4[C:77](=[C:78]([CH3:80])[CH:79]=3)[N:76]=[CH:75][C:74]([C:81]([NH2:83])=[O:82])=[C:73]4[NH:84][C:85]3[CH:90]=[CH:89][CH:88]=[C:87]([O:91][CH3:92])[CH:86]=3)(=[O:69])=[O:68])[CH:64]=[CH:65][CH:66]=2)=[O:60])=[CH:54][CH:53]=1>>[CH3:92][O:91][C:87]1[CH:86]=[C:85]([NH:84][C:73]2[C:72]3[C:77](=[C:78]([CH3:80])[CH:79]=[C:70]([S:67]([C:63]4[CH:64]=[CH:65][CH:66]=[C:61]([C:59](=[O:60])[NH:58][C:55]5[CH:56]=[CH:57][C:52]([C:51]#[C:50][CH2:49][CH2:48][CH2:47][CH:46]=[O:45])=[CH:53][CH:54]=5)[CH:62]=4)(=[O:69])=[O:68])[CH:71]=3)[N:76]=[CH:75][C:74]=2[C:81]([NH2:83])=[O:82])[CH:90]=[CH:89][CH:88]=1

Participants

3

Reactant 2

HCID 669882776-((3-((4-(6-Hydroxyhex-1-yn-1-yl)phenyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamideHCID 866590914-[(3-Methoxyphenyl)amino]-8-methyl-6-[[3-[(8-oxooctyl)carbamoyl]phenyl]sulfonyl]quinoline-3-carboxamide

Product 1

HCID 86659094HCID 86659094, compound

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 112, using instead Intermediate 76 as substrate. ES/MS calcd. for C37H33N4O6S+ 661.2. Found m/z=663.1 (M+H)+.

Sources & evidence

ORD record
ord-f484fffa9c71404eaf0e6e87d0de9e63
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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