HCID 66988062, compound → 4-((3-Methoxyphenyl)amino)-8-methyl-6-((3-(4-(6-oxohexyl)piperazine-1-carbonyl)phenyl)sulfonyl)quinoline-3-carboxamide

HRID 1944934Notes

Reaction equation

HRID 1944934 reaction equation
COC1C=C(NC2C3C(=C(C)C=C(S(C4C=CC=C(C(=O)NCCCCCCCC=O)C=4)(=O)=O)C=3)N=CC=2C(N)=O)C=CC=1.[OH:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][N:52]1[CH2:57][CH2:56][N:55]([C:58]([C:60]2[CH:61]=[C:62]([S:66]([C:69]3[CH:70]=[C:71]4[C:76](=[C:77]([CH3:79])[CH:78]=3)[N:75]=[CH:74][C:73]([C:80]([NH2:82])=[O:81])=[C:72]4[NH:83][C:84]3[CH:89]=[CH:88][CH:87]=[C:86]([O:90][CH3:91])[CH:85]=3)(=[O:68])=[O:67])[CH:63]=[CH:64][CH:65]=2)=[O:59])[CH2:54][CH2:53]1>>[CH3:91][O:90][C:86]1[CH:85]=[C:84]([NH:83][C:72]2[C:71]3[C:76](=[C:77]([CH3:79])[CH:78]=[C:69]([S:66]([C:62]4[CH:63]=[CH:64][CH:65]=[C:60]([C:58]([N:55]5[CH2:56][CH2:57][N:52]([CH2:51][CH2:50][CH2:49][CH2:48][CH2:47][CH:46]=[O:45])[CH2:53][CH2:54]5)=[O:59])[CH:61]=4)(=[O:68])=[O:67])[CH:70]=3)[N:75]=[CH:74][C:73]=2[C:80]([NH2:82])=[O:81])[CH:89]=[CH:88][CH:87]=1

Participants

3

Reactant 2

HCID 66988062HCID 66988062, compoundHCID 86659091HCID 86659091, compound

Product 1

HCID 866590964-((3-Methoxyphenyl)amino)-8-methyl-6-((3-(4-(6-oxohexyl)piperazine-1-carbonyl)phenyl)sulfonyl)quinoline-3-carboxamide

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 112, using Intermediate 89 as a substrate. ES/MS calcd. for C35H40N5O6S+ 658.3. Found m/z=658.3 (M+H)+.

Sources & evidence

ORD record
ord-03bfe9fc4aeb4a8dbe1071ccdfa5bf13
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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