HCID 66988508, compound → 4-((3-Methoxyphenyl)amino)-8-methyl-6-((4'-(3-oxopropyl)-[1,1'-biphenyl]-4-yl)sulfonyl)quinoline-3-carboxamide

HRID 1944941Notes

Reaction equation

HRID 1944941 reaction equation
COC1C=C(NC2C3C(=C(C)C=C(S(C4C=CC=C(C(=O)NC5C=CC(C6C=CC(CCCC=O)=CC=6)=CC=5)C=4)(=O)=O)C=3)N=CC=2C(N)=O)C=CC=1.[OH:53][CH2:54][CH2:55][CH2:56][C:57]1[CH:62]=[CH:61][C:60]([C:63]2[CH:68]=[CH:67][C:66]([S:69]([C:72]3[CH:73]=[C:74]4[C:79](=[C:80]([CH3:82])[CH:81]=3)[N:78]=[CH:77][C:76]([C:83]([NH2:85])=[O:84])=[C:75]4[NH:86][C:87]3[CH:92]=[CH:91][CH:90]=[C:89]([O:93][CH3:94])[CH:88]=3)(=[O:71])=[O:70])=[CH:65][CH:64]=2)=[CH:59][CH:58]=1>>[CH3:94][O:93][C:89]1[CH:88]=[C:87]([NH:86][C:75]2[C:74]3[C:79](=[C:80]([CH3:82])[CH:81]=[C:72]([S:69]([C:66]4[CH:65]=[CH:64][C:63]([C:60]5[CH:61]=[CH:62][C:57]([CH2:56][CH2:55][CH:54]=[O:53])=[CH:58][CH:59]=5)=[CH:68][CH:67]=4)(=[O:70])=[O:71])[CH:73]=3)[N:78]=[CH:77][C:76]=2[C:83]([NH2:85])=[O:84])[CH:92]=[CH:91][CH:90]=1

Participants

3

Reactant 2

HCID 66988508HCID 66988508, compoundHCID 866590984-((3-Methoxyphenyl)amino)-8-methyl-6-((3-((4'-(4-oxobutyl)-(1,1-biphenyl]-4-yl)carbamoyl)phenyl)sulfonyl)quinoline-3-carboxamide

Product 1

HCID 866591034-((3-Methoxyphenyl)amino)-8-methyl-6-((4'-(3-oxopropyl)-[1,1'-biphenyl]-4-yl)sulfonyl)quinoline-3-carboxamide

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 124, using Intermediate 66 as a substrate. ES/MS calcd. for C33H30N3O5S+ 580.2. Found m/z=580.3 (M+H)+.

Sources & evidence

ORD record
ord-65251c6934cd48f182717b83b3014434
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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