Water → HCID 66988709, compound

Participants

Reaction Steps

LAH (158 mg, 3.96 mmol) was added to a stirring solution of methyl 3-[[3-carbamoyl-4-[(3-methoxyphenyl)amino]-8-methylquinolin-6-yl]sulfonyl]benzoate (500 mg, 0.99 mmol) in THF (10 mL) at 0° C. After stirring for 20 min, H2O (0.158 mL), 15% (w/v) NaOH (0.158 mL), and H2O (0.474 mL) were added sequentially. The resulting suspension was stirred for 1 h then the precipitate was filtered, washed with water (20 mL), and dried to give the title compound (330 mg) as a yellow solid. The compound was used with no further purification. ES/MS calcd. for C25H24N3O5S+ 478.1. Found m/z=478.1 (M+H)+.

Provenance & Evidence