(R)-6-[[3-[[4-[2-[[2-[8-(Benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2-hydroxyethyl]amino]ethyl]-phenyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide → (R)-6-((3-((3-(2-((2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethyl)amino)-2-methylpropyl)-N-methylbenzamido)methyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

HRID 1944956Notes

Reaction equation

C(OC1C=CC([C@@H](O)CNCCC2C=CC(NC(C3C=C(S(C4C=C5C(=C(C)C=4)N=CC(C(N)=O)=C5NC4C=CC=C(OC)C=4)(=O)=O)C=CC=3)=O)=CC=2)=C2C=1NC(=O)C=C2)C1C=CC=CC=1.[CH2:67]([O:74][C:75]1[CH:76]=[CH:77][C:78]([C@@H:86]([O:136][Si](C(C)(C)C)(C)C)[CH2:87][NH:88][C:89]([CH3:135])([CH3:134])[CH2:90][C:91]2[CH:92]=[C:93]([CH:131]=[CH:132][CH:133]=2)[C:94]([N:96]([CH2:98][C:99]2[CH:100]=[C:101]([S:105]([C:108]3[CH:109]=[C:110]4[C:115](=[C:116]([CH3:118])[CH:117]=3)[N:114]=[CH:113][C:112]([C:119]([NH2:121])=[O:120])=[C:111]4[NH:122][C:123]3[CH:128]=[CH:127][CH:126]=[C:125]([O:129][CH3:130])[CH:124]=3)(=[O:107])=[O:106])[CH:102]=[CH:103][CH:104]=2)[CH3:97])=[O:95])=[C:79]2[C:84]=1[NH:83][C:82](=[O:85])[CH:81]=[CH:80]2)[C:68]1[CH:73]=[CH:72][CH:71]=[CH:70][CH:69]=1>>[CH2:67]([O:74][C:75]1[CH:76]=[CH:77][C:78]([C@@H:86]([OH:136])[CH2:87][NH:88][C:89]([CH3:134])([CH3:135])[CH2:90][C:91]2[CH:92]=[C:93]([CH:131]=[CH:132][CH:133]=2)[C:94]([N:96]([CH2:98][C:99]2[CH:100]=[C:101]([S:105]([C:108]3[CH:109]=[C:110]4[C:115](=[C:116]([CH3:118])[CH:117]=3)[N:114]=[CH:113][C:112]([C:119]([NH2:121])=[O:120])=[C:111]4[NH:122][C:123]3[CH:128]=[CH:127][CH:126]=[C:125]([O:129][CH3:130])[CH:124]=3)(=[O:107])=[O:106])[CH:102]=[CH:103][CH:104]=2)[CH3:97])=[O:95])=[C:79]2[C:84]=1[NH:83][C:82](=[O:85])[CH:81]=[CH:80]2)[C:68]1[CH:69]=[CH:70][CH:71]=[CH:72][CH:73]=1

Participants

Reactant 2

HCID 86659111(R)-6-[[3-[[4-[2-[[2-[8-(Benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2-hydroxyethyl]amino]ethyl]-phenyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

HCID 86659115(R)-6-((3-((3-(2-((2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2-methylpropyl)-N-methylbenzamido)methyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

Product 1

HCID 86659114(R)-6-((3-((3-(2-((2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethyl)amino)-2-methylpropyl)-N-methylbenzamido)methyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 144, using Intermediate 143 as a substrate. ES/MS calcd. for C55H54N6NaO8S+ 981.4. Found m/z=981.4 (M+Na)+.

Sources & evidence

ORD record: ord-d2fd0472e9a04e13a318d1274fb21643
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394829B2

Reaction notes

Loading…