HRID1944958

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)O[C@@H](CN)c1ccc(O)c2c1OCC(=O)N2

HCID66988956

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(-c6ccc(CCCC=O)cc6)cc5)c4)cc23)c1

HCID86659098

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)NCCCCCCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c5ccc(O)c6[nH]c(=O)ccc56)c4)cc23)c1

HCID86659116

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(-c6ccc(CCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c7ccc(O)c8c7OCC(=O)N8)cc6)cc5)c4)cc23)c1

HCID86659117

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described for Intermediate 148, using (R)-8-(2-amino-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one in place of Intermediate 2 and Intermediate 124 in place of Intermediate 112. ES/MS calcd. for C57H63N6O9SSi+ 1035.4. Found m/z=1035.6 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8fb8c278bdf1422189c73c0cce382aa2
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394829B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Si](O[C@H](C1C=CC(O)=C2C=1C=CC(=O)N2)CNCCCCCCCCNC(C1C=C(S(C2C=C3C(=C(C)C=2)N=CC(C(N)=O)=C3NC2C=CC=C(OC)C=2)(=O)=O)C=CC=1)=O)(C(C)(C)C)(C)C.[NH2:67][CH2:68][C@@H:69]([C:78]1[C:83]2[O:84][CH2:85][C:86](=[O:88])[NH:87][C:82]=2[C:81]([OH:89])=[CH:80][CH:79]=1)[O:70][Si:71]([C:74]([CH3:77])([CH3:76])[CH3:75])([CH3:73])[CH3:72].[CH3:90][O:91][C:92]1[CH:93]=[C:94]([NH:98][C:99]2[C:108]3[C:103](=[C:104]([CH3:138])[CH:105]=[C:106]([S:109]([C:112]4[CH:117]=[CH:116][CH:115]=[C:114]([C:118](=[O:137])[NH:119][C:120]5[CH:125]=[CH:124][C:123]([C:126]6[CH:131]=[CH:130][C:129]([CH2:132][CH2:133][CH2:134][CH:135]=O)=[CH:128][CH:127]=6)=[CH:122][CH:121]=5)[CH:113]=4)(=[O:111])=[O:110])[CH:107]=3)[N:102]=[CH:101][C:100]=2[C:139]([NH2:141])=[O:140])[CH:95]=[CH:96][CH:97]=1>>[Si:71]([O:70][C@H:69]([C:78]1[C:83]2[O:84][CH2:85][C:86](=[O:88])[NH:87][C:82]=2[C:81]([OH:89])=[CH:80][CH:79]=1)[CH2:68][NH:67][CH2:135][CH2:134][CH2:133][CH2:132][C:129]1[CH:130]=[CH:131][C:126]([C:123]2[CH:122]=[CH:121][C:120]([NH:119][C:118]([C:114]3[CH:113]=[C:112]([S:109]([C:106]4[CH:107]=[C:108]5[C:103](=[C:104]([CH3:138])[CH:105]=4)[N:102]=[CH:101][C:100]([C:139]([NH2:141])=[O:140])=[C:99]5[NH:98][C:94]4[CH:95]=[CH:96][CH:97]=[C:92]([O:91][CH3:90])[CH:93]=4)(=[O:110])=[O:111])[CH:117]=[CH:116][CH:115]=3)=[O:137])=[CH:125][CH:124]=2)=[CH:127][CH:128]=1)([C:74]([CH3:77])([CH3:75])[CH3:76])([CH3:73])[CH3:72]