HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(3-Methoxyphenyl)amino]-8-methyl-6-[[3-[[4-(5-oxopent-1-yn-1-yl)phenyl]carbamoyl]phenyl]sulfonyl]quinoline-3-carboxamide → (R)-6-[[3-[[4-[5-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]pent-1-ynyl]-phenyl]carbamoyl]phenyl]-sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(3-Methoxyphenyl)amino]-8-methyl-6-[[3-[[4-(5-oxopent-1-yn-1-yl)phenyl]carbamoyl]phenyl]sulfonyl]quinoline-3-carboxamide | HCID 58505179 | — |
| Reactant | (R)-6-[[3-[[8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | HCID 86659116 | — |
| Product | (R)-6-[[3-[[4-[5-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]pent-1-ynyl]-phenyl]carbamoyl]phenyl]-sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | HCID 58505204 | — |
Reaction Steps
The title compound was synthesized in a manner analogous to that described for Intermediate 148, using Intermediate 115 in place of Intermediate 112. ES/MS calcd. for C53H57N6O8SSi+ 965.4. Found m/z=965.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394829B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-a4f114a566e9438c8c3a8afaa71022a0 |
| Source note | uspto-grants-2013_03 |