HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-6-[[3-[[8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide → (R)-6-((3-((4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)pent-1-yn-1-yl)-2-methylphenyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-6-[[3-[[8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | HCID 86659116 | — |
| Reactant | 4-((3-Methoxyphenyl)amino)-8-methyl-6-((3-((2-methyl-4-(5-oxopent-1-yn-1-yl)phenyl)carbamoyl)phenyl)sulfonyl)quinoline-3-carboxamide | HCID 86659119 | — |
| Product | (R)-6-((3-((4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)pent-1-yn-1-yl)-2-methylphenyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide | HCID 86659118 | — |
Reaction Steps
The title compound was synthesized in a manner analogous to that described in Intermediate 148, using Intermediate 117 in place of Intermediate 112. ES/MS calcd. for C52H56N6O9SSi 978.4. Found m/z=979 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394829B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-74d87aba11a14e77921f8fc73a91f5d0 |
| Source note | uspto-grants-2013_03 |