HCID 58505222, compound → (R)-6-((3-((4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide
Reaction equation
OCCCCCCCCN[C:11]([C:13]1[CH:14]=[C:15]([S:19]([C:22]2[CH:23]=[C:24]3[C:29](=[C:30]([CH3:32])[CH:31]=2)[N:28]=[CH:27][C:26]([C:33]([NH2:35])=[O:34])=[C:25]3[NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([O:43][CH3:44])[CH:38]=2)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1)=[O:12].[NH2:45][C:46]1[CH:51]=[CH:50][C:49]([C:52]#[C:53][CH2:54][CH2:55][CH2:56][N:57]([CH3:80])[CH2:58][C@@H:59]([C:68]2[CH:77]=[CH:76][C:75]([OH:78])=[C:74]3[C:69]=2[CH:70]=[CH:71][C:72](=[O:79])[NH:73]3)[O:60][Si:61]([C:64]([CH3:67])([CH3:66])[CH3:65])([CH3:63])[CH3:62])=[CH:48][CH:47]=1>>[Si:61]([O:60][C@H:59]([C:68]1[CH:77]=[CH:76][C:75]([OH:78])=[C:74]2[C:69]=1[CH:70]=[CH:71][C:72](=[O:79])[NH:73]2)[CH2:58][N:57]([CH3:80])[CH2:56][CH2:55][CH2:54][C:53]#[C:52][C:49]1[CH:50]=[CH:51][C:46]([NH:45][C:11]([C:13]2[CH:14]=[C:15]([S:19]([C:22]3[CH:23]=[C:24]4[C:29](=[C:30]([CH3:32])[CH:31]=3)[N:28]=[CH:27][C:26]([C:33]([NH2:35])=[O:34])=[C:25]4[NH:36][C:37]3[CH:42]=[CH:41][CH:40]=[C:39]([O:43][CH3:44])[CH:38]=3)(=[O:20])=[O:21])[CH:16]=[CH:17][CH:18]=2)=[O:12])=[CH:47][CH:48]=1)([C:64]([CH3:67])([CH3:66])[CH3:65])([CH3:62])[CH3:63]Participants
3
Reactant 2
Product 1
Procedure
The title compound was synthesized in a manner analogous to that described for Intermediate 70, using Intermediate 103 in place of 8-aminooctanol. ES/MS calcd. for C54H59N6O8SSi+ 979.4. Found m/z=979.6 (M+H)+.
Sources & evidence
- ORD record
- ord-90875775481e45c8a4d834bbd30375b9
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08394829B2
Reaction notes
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