HRID1944967

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(-c6ccc(CCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c7ccc(O)c8c7OCC(=O)N8)cc6)cc5)c4)cc23)c1

HCID86659117

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(C#CCCC=O)cc5C)c4)cc23)c1

HCID86659119

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(C#CCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c6ccc(O)c7c6OCC(=O)N7)cc5C)c4)cc23)c1

HCID86659125

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described in Intermediate 151, using Intermediate 117 in place of Intermediate 124. ES/MS calcd. for C53H58N6O9SSi 982.4. Found m/z=983 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b06fe899809f434aac7a2113b17e7da9
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394829B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Si:1]([O:8][C@H:9]([C:63]1[C:68]2[O:69][CH2:70][C:71](=[O:73])[NH:72][C:67]=2[C:66]([OH:74])=[CH:65][CH:64]=1)[CH2:10][NH:11][CH2:12][CH2:13]CCC1C=CC(C2C=CC(NC(C3C=C(S(C4C=C5C(=C(C)C=4)N=CC(C(N)=O)=C5NC4C=CC=C(OC)C=4)(=O)=O)C=CC=3)=O)=CC=2)=CC=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH3:75][O:76][C:77]1[CH:78]=[C:79]([NH:83][C:84]2[C:93]3[C:88](=[C:89]([CH3:119])[CH:90]=[C:91]([S:94]([C:97]4[CH:102]=[CH:101][CH:100]=[C:99]([C:103](=[O:118])[NH:104][C:105]5[CH:110]=[CH:109][C:108]([C:111]#[C:112][CH2:113]CC=O)=[CH:107][C:106]=5[CH3:117])[CH:98]=4)(=[O:96])=[O:95])[CH:92]=3)[N:87]=[CH:86][C:85]=2[C:120]([NH2:122])=[O:121])[CH:80]=[CH:81][CH:82]=1>>[Si:1]([O:8][C@H:9]([C:63]1[C:68]2[O:69][CH2:70][C:71](=[O:73])[NH:72][C:67]=2[C:66]([OH:74])=[CH:65][CH:64]=1)[CH2:10][NH:11][CH2:12][CH2:13][CH2:113][C:112]#[C:111][C:108]1[CH:109]=[CH:110][C:105]([NH:104][C:103]([C:99]2[CH:98]=[C:97]([S:94]([C:91]3[CH:92]=[C:93]4[C:88](=[C:89]([CH3:119])[CH:90]=3)[N:87]=[CH:86][C:85]([C:120]([NH2:122])=[O:121])=[C:84]4[NH:83][C:79]3[CH:80]=[CH:81][CH:82]=[C:77]([O:76][CH3:75])[CH:78]=3)(=[O:95])=[O:96])[CH:102]=[CH:101][CH:100]=2)=[O:118])=[C:106]([CH3:117])[CH:107]=1)([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:3])[CH3:2]