HRID1944974

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)O[C@@H](CN)c1cc(O)cc2c1OCC(=O)N2

HCID66988084

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)CCCCCCCCCCC=O)cc23)c1

HCID86659100

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)NCCCCCCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c5ccc(O)c6[nH]c(=O)ccc56)c4)cc23)c1

HCID86659116

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)CCCCCCCCCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c4cc(O)cc5c4OCC(=O)N5)cc23)c1

HCID66988392

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described for Intermediate 148, using (R)-8-(2-amino-1-((tert-butyldimethylsilyl)oxy)ethyl)-6-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one in place of Intermediate 2 and Intermediate 126 in place of Intermediate 112. ES/MS calcd. for C45H64N5O8SSi+ 862.4. Found m/z=862.6 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-626d6352112949889f575fa441abfab1
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394829B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Si](O[C@H](C1C=CC(O)=C2C=1C=CC(=O)N2)CNCCCCCCCCNC(C1C=C(S(C2C=C3C(=C(C)C=2)N=CC(C(N)=O)=C3NC2C=CC=C(OC)C=2)(=O)=O)C=CC=1)=O)(C(C)(C)C)(C)C.[NH2:67][CH2:68][C@@H:69]([C:78]1[C:83]2[O:84][CH2:85][C:86](=[O:88])[NH:87][C:82]=2[CH:81]=[C:80]([OH:89])[CH:79]=1)[O:70][Si:71]([C:74]([CH3:77])([CH3:76])[CH3:75])([CH3:73])[CH3:72].[CH3:90][O:91][C:92]1[CH:93]=[C:94]([NH:98][C:99]2[C:108]3[C:103](=[C:104]([CH3:124])[CH:105]=[C:106]([S:109]([CH2:112][CH2:113][CH2:114][CH2:115][CH2:116][CH2:117][CH2:118][CH2:119][CH2:120][CH2:121][CH:122]=O)(=[O:111])=[O:110])[CH:107]=3)[N:102]=[CH:101][C:100]=2[C:125]([NH2:127])=[O:126])[CH:95]=[CH:96][CH:97]=1>>[Si:71]([O:70][C@H:69]([C:78]1[C:83]2[O:84][CH2:85][C:86](=[O:88])[NH:87][C:82]=2[CH:81]=[C:80]([OH:89])[CH:79]=1)[CH2:68][NH:67][CH2:122][CH2:121][CH2:120][CH2:119][CH2:118][CH2:117][CH2:116][CH2:115][CH2:114][CH2:113][CH2:112][S:109]([C:106]1[CH:107]=[C:108]2[C:103](=[C:104]([CH3:124])[CH:105]=1)[N:102]=[CH:101][C:100]([C:125]([NH2:127])=[O:126])=[C:99]2[NH:98][C:94]1[CH:95]=[CH:96][CH:97]=[C:92]([O:91][CH3:90])[CH:93]=1)(=[O:111])=[O:110])([C:74]([CH3:77])([CH3:75])[CH3:76])([CH3:73])[CH3:72]