Trifluoroacetic acid → HCID 54588736, compound

Participants

Reaction Steps

The concentrated reaction mixture containing Intermediate 159 was taken up in dichloromethane (5 mL) and treated with trifluoroacetic acid (1 mL). After stirring overnight at room temperature, the mixture was concentrated under reduced pressure. The residue was taken up in tetrahydrofuran (1 mL) and treated with TBAF solution (1.0 M in THF, 1 mL) and glacial acetic acid (0.30 mL). The mixture was stirred overnight in a 40° C. oil bath, and then concentrated under reduced pressure. The residue was purified by reverse-phase high performance liquid chromatography (RP-HPLC, acetonitrile/water/0.1% TFA) to provide, after concentration, the trifluoroacetic acid salt of the title compound as a yellow powder (16 mg).

Provenance & Evidence