1-(2-Methoxyphenyl)piperazine → HCID 24205899, compound

Participants

Reaction Steps

To a compound of N1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-chloroacetamide (600 mg, 1.74 mmol) in dry acetone (20 mL) was added anhydrous potassium carbonate (1.21 g, 8.78 mmol) and 1-(2-methoxyphenyl)piperazine (336 mg, 1.98 mmol). The reaction mixture was refluxed for 24 h and the reaction was monitored by TLC using ethyl acetate-hexane (6:4) as a solvent system. The potassium carbonate was then removed by suction filtration and the solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate:hexane (6:4) as a solvent system to obtain the pure product 6c (780 mg, 89% yield).

Provenance & Evidence