Acetone → HCID 25030339, compound

Participants

Reaction Steps

reacting the above the N1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-piperazinoacetamide compound with (E)-3-[4-(3-bromopropoxy)-3-methoxyphenyl]-1-(4-luorophenyl)-2-propen-1-one or 3-(3-bromopropoxy)-2-phenyl-4H-4-chromenone in acetone in the presence potassium carbonate, under reflux, for a period of about 15 to about 20 hrs, followed by the removal of potassium carbonate by alteration and evaporating the solvent, under vacuum, and purifying the resultant product to obtain N1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-[4-(4-4-[(E)-3-(4-fluorophenyl)-3-oxo-1-propenyl]-2-methoxyphenoxy butyl)piperazino]acetamide or N1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-2-(4-3-[(4-oxo-3-phenyl-4H-2-chromenyl)oxy]propylpiperazino)acetamide.

Provenance & Evidence