HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[1-biphenyl-4-yl-meth-(Z)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester → 2-Biphenyl-4-ylmethyl-succinic acid 4-tert-butyl ester 1-methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[1-biphenyl-4-yl-meth-(Z)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester | HCID 68424531 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Biphenyl-4-ylmethyl-succinic acid 4-tert-butyl ester 1-methyl ester | HCID 68424697 | — |
Reaction Steps
A solution of 2-[1-biphenyl-4-yl-meth-(Z)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester (410 mg, 1.163 mmol) in ethyl acetate (20 mL) is hydrogenated over Pt/C (40 mg) at 1 atm for 18 hours. The catalyst is filtered through Celite and the solvent is removed under reduced pressure to give 2-biphenyl-4-ylmethyl-succinic acid 4-tert-butyl ester 1-methyl ester. The enantiomers are separated by chiral HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394853B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-e0c2417210e94454aa69ac77f9fbedf6 |
| Source note | uspto-grants-2013_03 |