反应详情

To a solution of ethyl 2-vinylthiazole-5-carboxylate (400 mg, 2.18 mmol) in MeOH (7 mL) is added 10% wt. Pd/C (267 mg, 0.25 mmol) at room temperature. After stirring at room temperature under a balloon of hydrogen for 1 hour, the crude is filtered to remove Pd/C. The filtrate is concentrated to give ethyl 2-ethylthiazole-5-carboxylate (404 mg). HPLC retention time=0.60 minutes (condition B); MS (m+1)=186.3; 1H NMR (400 MHz, CD3OD) δ ppm 1.35 (t, J=7.3 Hz, 2H) 1.39 (t, J=7.20 Hz, 2H) 3.07 (q, J=7.58 Hz, 2H) 4.35 (q, J=7.16 Hz, 2H) 8.22 (s, 1H)

1. filtrationthe crude is filtered
2. customto remove Pd/C
3. concentrationThe filtrate is concentrated