Stannous chloride dihydrate → HCID 68466877, compound

Participants

Reaction Steps

A solution of 3.80 g (12.5 mmol) of 4-(3-isopropylphenoxy)-2-chloro-5-methylnitrobenzene in 60 ml of dioxane and 60 ml of hydrochloric acid is admixed with 8.41 g (37.2 mmol) of tin(II) chloride dihydrate at room temperature and the mixture is then refluxed for 2 h. It is cooled to room temperature, neutralized with NaHCO3 and extracted repeatedly with dichloromethane, and the extracts are dried over Na2SO4 and filtered, and the solvent is removed under reduced pressure (3.47 g, 94.5% purity, 95.7% yield, log P (pH 2.3)=4.68).

Provenance & Evidence