HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → [4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]phenoxy]-acetic acid, 1,1-dimethylethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | 4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]-phenol | HCID 66996080 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]phenoxy]-acetic acid, 1,1-dimethylethyl ester | HCID 86659304 | — |
Reaction Steps
A mixture of the product from step (iii) (0.3 g), tert-butylbromoacetate (0.15 ml) and potassium carbonate (0.13 g) in DMF (20 ml) was stirred at RT overnight. The mixture was partitioned between water and ethylacetate, the organics separated, dried, and evaporated under reduced pressure. Yield 0.55 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394986B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-bf0738449cd443e38942eb8572d0aff4 |
| Source note | uspto-grants-2013_03 |