反应详情

A solution of butyl lithium (1.6M in hexane, 1.03 ml) was added to a stirred solution of the product from step (i) (0.5 g) in diethylether (20 ml) at −78° C. After 1 h, 4-ethylsulfanyl-benzaldehyde (0.25 g) was added and stirred for a further 1 h. The reaction was quenched with water, extracted with diethylether and the organic layer dried, then evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 50% diethylether/isohexane. Yield 0.7 g

1. customThe reaction was quenched with water
2. extractionextracted with diethylether
3. customthe organic layer dried
4. customevaporated under reduced pressure
5. customThe residue was purified by chromatography on silica eluting with 50% diethylether/isohexane