HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1945231Generated: October 31, 2026
Sodium Hydroxide → {2-[2-Chloro-4-(methylsulfonyl)phenoxy]phenoxy}acetic acid
https://huagongshe.com/reaction/1945231
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (o-Hydroxyphenoxy)acetic acid | HCID 22783 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-1-fluoro-4-methylsulfonylbenzene | HCID 21340880 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | {2-[2-Chloro-4-(methylsulfonyl)phenoxy]phenoxy}acetic acid | HCID 58516141 | — |
Reaction Steps
Sodium hydride (60% disp. oil, 0.24 g) was added to a solution of (2-hydroxyphenoxy)acetic acid (0.5 g) in DMF (20 ml) and stirred at 40° C. for 30 min. The product from example 7 step (ii) (0.62 g) was added, then the mixture heated at 75° C. for 30 h. 2M Sodium hydroxide solution was added and extracted with ethylacetate. The aqueous layer was acidified with 2M hydrochloric acid and extracted with ethyl acetate. The organics were dried, evaporated under reduced pressure and the residue purified by RPHPLC, yield 0.21 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08394986B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-734f0c66a7ce4a178217f2d354d27de8 |
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| Source note | uspto-grants-2013_03 |
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