HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1945232Generated: October 30, 2026
Water → 4-Bromo-1-(methylthio)-2-(trifluoromethyl)-benzene
https://huagongshe.com/reaction/1945232
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Bromo-2-fluorobenzotrifluoride | HCID 2736325 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-1-(methylthio)-2-(trifluoromethyl)-benzene | HCID 22315318 | — |
Reaction Steps
A mixture of sodium thiomethoxide (0.317 g) and 5-bromo-2-fluorobenzotrifluoride (1.0 g) in DMF (4 ml) was heated at 50° C. for 1 h then poured into water and extracted with isohexane. The organics were washed with brine, dried and evaporated under reduced pressure. Yield 0.762 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08394986B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-e83377896bd946b5b42a6d72ab3991f7 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
