2-Iodobenzoic acid → 5-Nonanone

Participants

Reaction Conditions

Reaction Steps

1.49 mg (0.006 mmol) of 2-iodobenzoic acid (product made in Aldrich company), 1.11 g (1.8 mmol) of powdered Oxone (registered trademark) and 433 mg (3 mmol) of 5-nonanol were added in 3.75 ml of nitromethane, and the mixture was heated at 70° C. while being stirred for 12 hours. After being heated, the mixture was cooled to room temperature, and the insoluble substance was removed by means of filtering. Water was added in the filtrate, extraction was carried out using diethyl ether. The organic phase was dried by using sodium sulfate, and then 5-nonanone was obtained by means of vacuum-concentration. The yield of the obtained 5-nonanone was determined and the result is shown in Table 1.

Provenance & Evidence