N-Iodosuccinimide → HCID 86640503, compound

Participants

Reaction Conditions

Reaction Steps

NIS (7.9 g, 35.1 mmol) was added to a solution of N-(biphenyl-4-ylmethyl)-3,5-difluoro-2-nitroaniline (10.86 g, 31.9 mmol) in AcOH (150 mL). After heating at 70° C. for 2 h, the reaction mixture was concentrated and partitioned between EtOAc and saturated aqueous NaHCO3. The organic phase was washed with brine, dried (Na2SO3) and concentrated. Recrystallization from DCM/hexanes afforded the desired product as a red solid.

Provenance & Evidence