Boron tribromide → HCID 59267686, compound

HRID 1945275Notes

Reaction equation

HRID 1945275 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([S:9]([NH:12][C:13](=[O:15])[CH3:14])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.B(Br)(Br)Br>C(Cl)Cl>[OH:2][C:3]1[CH:4]=[C:5]([S:9]([NH:12][C:13](=[O:15])[CH3:14])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 47480115HCID 47480115, compound

Product 1

HCID 59267686HCID 59267686, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of N-[(3-methoxyphenyl)sulfonyl]acetamide (0.4 g, 1.75 mmol) in DCM at 0° C. was added BBr3 and the reaction was stirred at rt for 2 h. The reaction was quenched with pH=4 buffer and extracted with EtOAc. The organic phase was dried (Na2SO4) and concentrated to afford the title compound. LC-MS: mile 216 (M+H)+ (0.5 min).

Workup

  1. customThe reaction was quenched with pH=4 buffer
  2. extractionextracted with EtOAc
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-c303cf3ca01646c6b9187bc52723d985
Source dataset
uspto-grants-2013_03
Patent number
US08394969B2

Reaction notes

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