Potassium Carbonate → HCID 68659508, compound

Participants

Reaction Steps

K2CO3 (1 M in water) (0.16 mL, 0.162 mmol) was added to a solution of methyl 5-{[5-(4-bromophenyl)-6-chloro-1H-benzimidazol-2-yl]oxy}-2-methylbenzoate (25.5 mg, 0.054 mmol), 3-fluorophenylboronic acid (9 mg, 0.068 mmol) and Pd(PPh3)4 (6 mg) in dioxane (1 mL). The reaction was microwaved at 150° C. for 8 minutes. Volatiles were removed. The residue was partitioned between EtOAc (50 mL), and water (50 mL). The aqueous phase was extracted with EtOAc (3×40 mL). Combined organics were washed with brine, dried (MgSO4), filtered and concentrated. Purification by HPLC eluting with 10-90% MeCN:water afforded the desired product.

Provenance & Evidence