Tetrabutylammonium Fluoride → HCID 59267497, compound

Participants

Reaction Steps

A solution of N-({3-[(5-biphenyl-4-yl-6-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1 H-benzimidazol-2-yl)oxy]phenyl}sulfonyl)acetamide (38 mg, 0.059 mmol) and tetrabutylammonium fluoride (1 M in THF) (0.234 mL) in THF (3 mL) was heated at 80° C. for 2 h. Volatiles were removed and the residue was purified by reverse HPLC eluting with MeCN/water to give the title compound. LC-MS: calculated for C27H20ClN3O4S 517.09, observed m/e 518 (M+H)+ (Rt 3.77 min).

Provenance & Evidence