Potassium Carbonate → HCID 68659477, compound

Participants

Reaction Conditions

Reaction Steps

K2CO3 (0.293 mL, 0.585 mmol) followed by Pd(PPh3)4 (6.76 mg, 5.85 μmol) were added to a solution of 4-Bromo 3-fluoro anisole (0.027 mL, 0.195 mmol) and 5-[(6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl)oxy]-2-methylbenzoic acid (122 mg, 0.219 mmol) in DMF (2 mL). The reaction was heated at 150° C. under microwave irradiation for 10 min. Volatiles were removed to afford the desired product, which was used in the next step without further purification.

Provenance & Evidence