Phthalic Anhydride → HCID 58978663, 화합물

참여 물질

반응 단계

2-Bromo-9,9-dimethyl-9H-fluorene (40 g, 1 eq, 0.146 mol) and phthalic anhydride (23.8 g, 1.1 eq, 0.161 mol) were placed in a reaction vessel, and dichloromethane (1 l) was added thereto. Aluminum chloride (29.2 g, 1.5 eq, 0.219 mol) was gradually added at 0° C., and the reaction mixture was stirred at room temperature for 12 hours. After the reaction was terminated, distilled water was gradually added at 0° C., and the reaction solution was extracted with an excess of dichloromethane and several times washed with distilled water. After solvent removal, the resultant solid was placed in a hexane (2 l)-containing vessel, washed, filtered, and dried to give 2-(7-bromo-9,9-dimethyl-9H-fluorene-2-carbonyl)benzoic acid (50.4 g, yield=82%).

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