Hydrochloric Acid → HCID 68993903, compound

Participants

Reaction Steps

A 3-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-isophthalic acid dimethyl ester (158.9 mg, 0.34 mmol) in 1,4-dioxane/H2O (1:1, 3.5 ml) was treated with LiOHH2O (56.2 mg, 1.34 mmol) at room temperature. The reaction mixture was then acidified with 10% HCl to PH 2, and then partitioned between ethyl acetate and brine. The organic phase was washed with water, dried (MgSO4 anh), and concentrated. The residue was purified by silica gel flash column chromatography (CH2CH2:MeOH=5:1) to give 3-[2-(4-Adamantan-1-yl-phenoxy)-acetylamino]-isophthalic acid as a white solid (161.7 mg, 100% yield).

Provenance & Evidence