Hydrochloric Acid → HCID 24811558, compound

Participants

Reaction Steps

3-(2-biphenyl-4-yl-acetylamino)-benzoic acid methyl ester (133.6 mg, 0.39 mmol) in THF/H2O (1:1, 4 mL) was treated with LiOHH2O (32.7 mg, 0.78 mmol) at room temperature. The reaction mixture was then acidified with 10% HCl to PH 2. Resulting mixture was collected by filtration, and recrystallized with mixture of CH2Cl2 and MeOH to give 3-(2-biphenyl-4-yl-acetylamino)-benzoic acid as a white solid (74.4 mg, 58.1% yield).

Provenance & Evidence