1,2-Dichloroethane → HCID 16124990, compound

Participants

Reaction Steps

To a solution of 3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-benzoic acid (50 mg, 0.123 mmol), 4-(2-aminoethyl)pyridine (22.59 mg, 0.184 mmol) and DIPEA (23.90 mg, 0.184 mmol) in DMF 1 mL was added EDC (35.45 mg, 0.184 mmol) and HOBt (24.99 mg, 0.184 mmol) at room temperature and continued stirring for 16 h at room temperature. Reaction mixture was diluted with ethyl acetate and sequentially washed with aqueous sodium bicarbonate, brine and water, and dried over MgSO4. The solvent was filtered and evaporated under reduced pressure to afford a crude solid, which was purified by column chromatography on silica gel (n-Hexane:EtoAC=1:5) to give 3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-N-(2-pyridine-4-yl-ethyl)benzamide as a colorless crystal (25 mg, 40% yield).

Provenance & Evidence