1,2-Dichloroethane → HCID 24812093, compound

Participants

Reaction Steps

To solution of (4-adamantan-1-yl-phenoxy)-acetic acid (50 mg, 0.17 mmol), 5-amino-4-picoline (28.32 mg, 0.26 mmol) and DIPEA (33.85 mg, 0.26 mmol) in DMF 1 mL was added EDC (50.2 mg, 0.26 mmol) and HOBt (35.39 mg, 0.26 mmol) at room temperature. Reaction mixture was stirred at room temperature. Resulting mixture poured onto ice cold water, was extracted with ethyl acetate, sequentially washed with aqueous sodium bicarbonate, brine and water, dried over anhydrous MgSO4, and concentrated under reduced pressure. The residue was purified by flash silica gel column chromatography (EtoAC:Hexane=1:9˜2:8) to give 2-(4-adamantan-1-yl-phenoxy)-N-(4-methyl-pyridine-2-yl)-acetamide as a colorless solid (0.033 g, 50% yield).

Provenance & Evidence