HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1945439Generated: October 26, 2026
Lithium iodide → 2-[2-(4-tert-butyl-phenoxy)acetylamino]-isonicotinic Acid
https://huagongshe.com/reaction/1945439
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium iodide | HCID 66321 | — |
| Reactant | 2-[2-(4-Tert-butyl-phenoxy)-acetylamino]-isonicotinic acid methyl ester | HCID 24812097 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-[2-(4-tert-butyl-phenoxy)acetylamino]-isonicotinic Acid | HCID 58001344 | 799.9% |
Reaction Steps
To solution of 2-[2-(4-tert-butyl-phenoxy)-acetylamino]-isonicotinic acid methyl ester (51.8 mg, 0.15 mmol) in pyridine 6 ml was added lithium Iodide (12.6 mg, 0.30 mmol), and stirred at 125° C. Reaction mixture was concentrated, and purified by Prep-TLC(CH2Cl2:MeOH=10:1) to give as a colorless solid (394 mg, 77.94% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08394799B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-9dcc5298cd7f4ac8a594878732af41ee |
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| Source note | uspto-grants-2013_03 |
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