1,2-Dichloroethane → HCID 58001342, compound

Participants

Reaction Steps

To solution of 2-[2-(2,4-dichloro-phenoxy)-acetylamino]-isonicotinic acid (100 mg, 0.31 mmol), 3-morpholine-4-propylamine (67.8 mg, 0.07 ml, 0.47 mmol), EDC (90.1 mg, 0.47 mmol) and HOBt (63.4 mg, 0.47 mmol) in DMF 4 ml was added DIPEA (60.7 mg, 0.08 ml, 0.47 mmol), and stirred. Reaction mixture was then partitioned between ethyl acetate and 10% HCl. The organic phase was washed with brine, dried over anhydrous MgSO4, and concentrated. The residue was purified by preparative-TLC(CH2Cl2:MeOH=6:1) to afford 2-[2-(2,4-dichloro-phenoxy)-acetylamino]-N-(3-morpholine-4-yl-propyl)isonicotinamide as a white solid (31.3 mg, 21.7% yield).

Provenance & Evidence