Methanol → HCID 24779732, compound

Participants

Reaction Steps

To solution of (4-adamantan-1-yl-phenoxy)acetic acid (70 mg, 0.24 mmol), 2-amino nicotinamide (50.28 mg, 0.36 mmol) and DMAP (59.77 mg, 0.48 mmol) in DMF 5 ml was added PyBOP (452 mg, 0.86 mmol), and stirred room temperature. Reaction mixture was poured onto ice cold water, diluted by methanol/MC mixture (10%). The organic phase was separated, sequentially washed with aqueous sodium bicarbonate, brine and water, dried over anhydrous MgSO4, and concentrated. The residue was purified by PLC (EtoAC:Hexane:MeOH=3:6:1-2:4:1) to afford 2-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-isonicotinamide as a colorless solid (0.05 g, 50% yield).

Provenance & Evidence