(2,4-Dichlorophenoxy)Acetic Acid → HCID 178497368, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,4-diamino-benzoic acid methyl ester (105.24 mg, 0.63 mmol) and 2,4-dichlorophenoxy acetic acid (100 mg, 0.45 mmol) in PPSE (1.5 mL) was heated at 160° C. for 4 h. At the end of the reaction period, the mixture was taken to 3 mL dichloromethane and neutralized with 4.5 mL 1 N NaOH solution. The organic layer was separated and the aqueous solution extracted with 3×3 mL portions of dichloromethane. The combined extracts were dried over anhydrous MgSO4, filtered and the solvent was removed with rotary evaporator under reduced pressure. The residue was purified by flash chromatography (EtOAc:Hexanes=1:1) to afford 2-(2,4-dichloro-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid methyl ester as a colorless powder (0.121 g, 52% yield).

Provenance & Evidence