Ethyl Acetate → HCID 178497369, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (4-nitro-butyl-phenoxy)-acetic acid (50 mg, 0.25 mmol) and 3,4-diaminobenzoic acid methyl ester (59 mg, 0.35 mmol) in PPSE was heated at 160° C. for 4 h. At the end of the reaction period, the mixture was taken to ethyl acetate and neutralized with aqueous sodium bicarbonate. The organic layer was separated and the aqueous solution extracted with ethyl acetate. The combined extracts were dried over anhydrous MgSO4, filtered and the solvent was removed with rotary evaporator under reduced pressure. The residue was purified by flash chromatography (MeOH:MC=0.5:9.5) to afford 2-(4-nitro-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid methyl ester as a colorless powder (66.4 mg, 80% yield).

Provenance & Evidence