Hydrochloric Acid → HCID 178524171, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2,4-dichlorophenoxymethyl)-1H-benzoimidazole-5-carboxylic acid methyl ester (110 mg, 0.31 mmol), acetic acid (60 mL) and coned HCl (60 mL) was heated under reflux for 3 h. At the end of the reaction period, the mixture was cooled to 10° C., neutralized with aqueous sodium bicarbonate solution, filtered, washed with ethyl acetate (10 mL), water (50 mL) and dried to afford 2-2,4-chloro-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid as a colorless powder (0.099 g, 94.28% yield).

Provenance & Evidence