Hydrochloric Acid → HCID 178441053, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-tert-butyl-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid methyl ester (150 mg, 0.44 mmol), acetic acid (30 mL) and concd HCl (39 mL) was heated under reflux for 3 h. At the end of the reaction period, the mixture was cooled to 10° C., neutralize with aqueous sodium bicarbonate solution, filtered, washed with ethyl acetate (10 mL), water (50 mL) and dried to afford 2-(4-tert-butyl-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid as a colorless powder (0.13 g, 90% yield).

Provenance & Evidence