Hydrochloric Acid → HCID 178524169, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-nitro-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid methyl ester (90 mg, 0.27 mmol), acetic acid (15 mL) and coned HCl (20 mL) was heated under reflux for 3 h. At the end of the reaction period, the mixture was cooled to 10° C., neutralize with aqueous sodium bicarbonate solution, filtered, washed with ethyl acetate (10 mL), water (50 mL) and dried to afford 2-(4-nitro-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid as a colorless powder (0.078 g, 90% yield).

Provenance & Evidence