1,2-Dichloroethane → HCID 24967620, compound

Participants

Reaction Steps

To solution of 2-(4-adamantan-1-yl-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid (44.8 mg, 0.11 mmol), dimethyl amine (0.4 mg, 0.23 mmol), EDC (44.1 mg, 0.23 mmol) and HOBt (31.3 mg, 0.23 mmol) in DMF 4.0 mL was added DIPEA (28.8 mg, 0.23 mmol, 0.04 ml). After stirring at room temperature, the mixture was partitioned between ethyl acetate and 10% HCl. The organic phase was washed with brine, dried (MgSO4 anh), and concentrated. The residue was purified by Prep-TLC (n-Hexane:EtoAc:MeOH=6:3:1) to give 2-(4-adamantan-1-yl-phenoxymethyl)-3H-benzoimidazole-5-carboxylic acid dimethylamide as a yellow solid (27.8 mg, 54.0% yield)

Provenance & Evidence