Dimethylformamide → HCID 178483813, compound

Participants

Reaction Steps

To solution of 2-(4-adamantan-1-yl-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid (70.0 mg, 0.18 mmol), N,N-diethylethylenediamine (23.8 mg, 0.27 mmol, 0.03 ml) and HBTU (136.5 mg, 0.36 mmol) in DMF 4.0 mL was added DIPEA (46.5 mg, 0.36 mmol, 0.06 ml). After stirring at room temperature, the mixture was partitioned between ethyl acetate and brine. The organic phase was dried (MgSO4 anh), and concentrated. The residue was purified by Prep-TLC(CH2Cl2:MeOH=10:1) to give 2-(4-adamantan-1-yl-phenoxymethyl)-1H-benzoimidazole-5-carboxylic acid (2-dimethylamino-ethyl)-amide as a yellow solid (21.9 mg, 25.8% yield).

Provenance & Evidence