Trifluoroacetic acid → HCID 59605760, compound

Participants

Reaction Steps

A mixture of 4-(methyl(oxetan-3-yl)amino)piperidine-1-carboxylic acid tert-butyl ester (150 mg, 0.55 mmol) and TFA (4 mL) in DCM (10 mL) was stirred at room temperature for 2 h. The reaction mixture was loaded onto an Isolute® SCX-2 cartridge which was washed with MeOH/DCM and the product eluted with 2M NH3/MeOH affording Methyl(oxetan-3-yl)piperidin-4-ylamine as a white solid (94 mg, quant.). 1H NMR (CDCl3, 300 MHz): δ 4.67 (t, J=6.7 Hz, 2 H); 4.61 (t, J=6.7 Hz, 2 H); 3.97 (p, J=6.7 Hz, 1 H); 3.14 (d, J=12.3 Hz, 2 H); 2.56 (td, J=12.2, 4.0 Hz, 2 H); 2.48-2.26 (m, 2 H); 2.22 (s, 3 H); 1.63 (d, J=12.3 Hz, 2 H); 1.40 (qd, J=12.2, 4.0 Hz, 2 H).

Provenance & Evidence