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Piperidine, 4-(1,1-dimethylethyl)- → 4-(8-((4-tert-butylpiperidin-1-yl)methyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine, 4-(1,1-dimethylethyl)- | HCID 74661 | — |
| 反応物 | 4-(8-(bromomethyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine | HCID 59603481 | — |
| 生成物 | 4-(8-((4-tert-butylpiperidin-1-yl)methyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine | HCID 59605988 | 68.1% |
反応手順
4-tert-butylpiperidine (0.45 g) was reacted with 4-(8-(bromomethyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine (1.0 g) via General Procedure C to yield 4-(8-((4-tert-butylpiperidin-1-yl)methyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine (0.80 g) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08394796B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-de5a9a06cf4c40789d30d5cb4225d4ee |
| 出典メモ | uspto-grants-2013_03 |