Acetic Acid → HCID 59605876, compound

HRID 1945773Notes

Reaction equation

HRID 1945773 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][O:16][C:15]([CH2:21][CH3:22])([CH2:19][CH3:20])[CH2:14]3)[N:8]2[CH3:11])=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:3]=1.[C:29]1([NH2:36])[C:30]([NH2:35])=[CH:31][CH:32]=[CH:33][CH:34]=1.[C:37](O)(=O)[CH3:38]>>[CH2:19]([C:15]1([CH2:21][CH3:22])[O:16][CH2:17][CH2:18][N:13]([CH2:12][C:7]2[N:8]([CH3:11])[C:9]3[C:5]([N:6]=2)=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:3]=[C:2]([N:35]2[C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=4[N:36]=[C:37]2[CH3:38])[N:10]=3)[CH2:14]1)[CH3:20]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 7243O-PhenylenediamineHCID 86648242HCID 86648242, compound

Product 1

HCID 59605876HCID 59605876, compound

Procedure

Following the procedures for 157 and General Procedure J, 4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-2,2-diethylmorpholine and benzene-1,2-diamine were reacted, followed by condensation with acetic acid to give 191. LCMS m/z: 505.3 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-916c115a47c84af7bf676d12fcf11c9a
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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