HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lactic Acid → HCID 59606120, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lactic Acid | HCID 612 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol | HCID 59603426 | — |
| Product | HCID 59606120 | HCID 59606120 | — |
Reaction Steps
Following the procedures for 157 and General Procedure J, 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol (1.21 g, 2.96 mmol) and benzene-1,2-diamine were reacted followed by condensation with lactic acid to give a racemic mixture. The enantiomers were separated by SFC to give 199. LCMS m/z: 535.3 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394796B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-b68d19c63df3474eacf41a46511a8aa5 |
| Source note | uspto-grants-2013_03 |