2-Methyl-2-(morpholin-4-yl)propan-1-amine → HCID 59605576, compound

HRID 1945782Notes

Reaction equation

HRID 1945782 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[CH3:19][C:20]([N:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)([CH3:23])[CH2:21][NH2:22]>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][NH:22][CH2:21][C:20]([CH3:23])([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[CH3:19])=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 19896412-Methyl-2-(morpholin-4-yl)propan-1-amineHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 59605576HCID 59605576, compound

Procedure

Following the procedures for 172, 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde and 2-methyl-2-morpholinopropan-1-amine were reacted by reductive amination to give N-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-2-methyl-2-morpholinopropan-1-amine, which was converted to the 2-tributylstannyl intermediate and reacted with 2-methyl-1H-benzo[d]imidazole to give 203. LCMS m/z: 522.2 (MH+)

Workup

  1. customwere reacted by reductive amination

Sources & evidence

ORD record
ord-7fbfa8dde0024f58a9f9b4b6831fdf40
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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